Tuscumbia is a city in and the county seat of Colbert County, Alabama, United States. As of the 2010 census, the population was 8,423. The city is part of The Shoals metropolitan area.Tuscumbia was the hometown of Helen Keller and much of the city is listed on the National Register of Historic Places as the Tuscumbia Historic District. The city serves as the location for the Alabama Music Hall of Fame.